Spike timing-dependent plasticity induces complexity in the brain
نویسندگان
چکیده
R. R. Borges, F. S. Borges, E. L. Lameu, A. M. Batista, K. C. Iarosz, I. L. Caldas, C. G. Antonopoulos, M. S. Baptista Pós-Graduação em Ciências, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil. Departamento de Matemática, Universidade Tecnológica Federal do Paraná, 86812-460, Apucarana, PR, Brazil. Departamento de Matemática e Estat́ıstica, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil. Instituto de F́ısica, Universidade de São Paulo, São Paulo, SP, Brazil. Department of Mathematical Sciences, University of Essex, Wivenhoe Park, UK. Institute for Complex Systems and Mathematical Biology, Aberdeen, SUPA, UK. (Dated: January 11, 2016)
منابع مشابه
Spike timing dependent plasticity: mechanisms, significance, and controversies
Long-term modification of synaptic strength is one of the basic mechanisms of memory formation and activity-dependent refinement of neural circuits. This idea was purposed by Hebb to provide a basis for the formation of a cell assembly. Repetitive correlated activity of pre-synaptic and post-synaptic neurons can induce long-lasting synaptic strength modification, the direction and extent of whi...
متن کاملSpike timing dependent plasticity: mechanisms, significance, and controversies
Long-term modification of synaptic strength is one of the basic mechanisms of memory formation and activity-dependent refinement of neural circuits. This idea was purposed by Hebb to provide a basis for the formation of a cell assembly. Repetitive correlated activity of pre-synaptic and post-synaptic neurons can induce long-lasting synaptic strength modification, the direction and extent of whi...
متن کاملEmergence of slow collective oscillations in neural networks with spike-timing dependent plasticity.
The collective dynamics of excitatory pulse coupled neurons with spike-timing dependent plasticity is studied. The introduction of spike-timing dependent plasticity induces persistent irregular oscillations between strongly and weakly synchronized states, reminiscent of brain activity during slow-wave sleep. We explain the oscillations by a mechanism, the Sisyphus Effect, caused by a continuous...
متن کاملBeyond spike-timing-dependent plasticity: a computational study of plasticity gradients across basal dendrites
Synaptic plasticity is thought to be the principal mechanism underlying learning in the brain. The majority of plastic networks in computational neuroscience combine point neurons with spike-timing-dependent plasticity (STDP) as the learning rule. However, a point neuron does not capture the complexity of dendrites. These long branches emanating from the soma allow nonlinear local processing of...
متن کاملRequirement of an allosteric kinetics of NMDA receptors for spike timing-dependent plasticity.
Spike timing-dependent synaptic plasticity (STDP) plays an important role in neural development and information processing in the brain; however, the mechanism by which spike timing information is encoded into STDP remains unclear. Here, we show that a novel allosteric kinetics of NMDA receptors (NMDARs) is required for STDP. We developed a detailed biophysical model of STDP and found that the ...
متن کاملSpike-Timing-Dependent Plasticity in the Intact Brain: Counteracting Spurious Spike Coincidences
A computationally rich algorithm of synaptic plasticity has been proposed based on the experimental observation that the sign and amplitude of the change in synaptic weight is dictated by the temporal order and temporal contiguity between pre- and postsynaptic activities. For more than a decade, this spike-timing-dependent plasticity (STDP) has been studied mainly in brain slices of different b...
متن کامل